Scientific Leader, Discovery Chemistry

We are currently looking for a highly motivated Organic Chemist to join our Medicinal Chemistry team in suburban Philadelphia. The Discovery Chemistry group partners with teams across GSK's research units to deliver high quality small molecules/novel modalities, from hit generation through late-stage lead optimization. The purpose of this role is to provide scientific leadership to teams within the Discovery Chemistry Department and/or multidisciplinary teams across GSK's R&D organization as well as partner with our Molecular Modality Capability group to embed new capabilities within Discovery Chemistry.

The successful candidate will work with business partners to build strategic project plans to support GSK's small molecule portfolio and deliver medical chemistry objectives from those plans. This person will also be accountable for identifying appropriate opportunities within the discovery chemistry portfolio to apply capabilities such as high throughput experimentation, direct to biology arrays, and high throughput chemistry and work across lines to effectively resource these opportunities. You must be able to think strategically and flexibly, be driven by the needs of the organization, and be able to work collaboratively. Moreover, this role requires a drive for continuous self-improvement and active contribution to a fantastic work culture that enables everyone to succeed together.

Key Responsibilities include, but are not limited to:

• Maintain a laboratory presence.

• Lead matrix team of high throughput chemistry/direct-to-biology/high throughput experimentation experts within discovery chemistry to partner with Molecular Modality Capabilities to deploy the latest advancements in chemistry and new technologies best equipped to address scientific hypotheses.

• Work with matrix teams to define strategic project plans, identifying key inflection points for discovery chemistry.

• Scientific leadership of projects within the discovery chemistry portfolio.

• Lead and motivate teams with vision, integrity, flexibility, and clear communication.

• Contribute to peer review of programs within the Discovery Chemistry portfolio.

• Serve as a coach and/or mentor within Discovery Chemistry.

• Lead teams of scientists in the development of novel approaches for the design and synthesis of cutting-edge modalities, for example: degraders, oligonucleotides, and antibody-drug conjugates.

Why you?

Basic Qualifications & Skills:

• Ph.D. in Chemistry, Organic Chemistry, Biochemistry, or a relevant scientific discipline; or MS or BS with 10+ years of experience in synthetic methods.

• 1+ year experience implementing high throughput chemistry, direct to biology, and/or high throughput experimentation.

• 3+ years of leadership experience leading chemistry projects or series to formulate and implement strategy to deliver milestones and achieve scientific or organizational goals.

Preferred Qualifications & Skills:

• Industrial or biotechnology experience of at least 7 years.

• Expertise with various synthesis platforms and instrumentation commonly used in modern medicinal chemistry.

• Multiple previous experiences of leadership of scientific projects or initiatives, with examples of developing team members.

• Previous leadership experience motivating and driving a high level of performance from individuals and teams.

• Demonstration of strategic oversight of business-related programs, projects, or platforms.

• Practical experience in the design, preparation, purification and analysis of oligonucleotides, antibody drug conjugates, or targeted protein degraders.

• Record of high-impact publication in peer reviewed journals.

• Effective people and cultural skills as evidenced by successful collaborations with multidisciplinary teams.

• Excellent written and oral communication skills enabling efficient presentation of scientific findings to both technical and non-technical audiences.

• Demonstrated creativity and innovation in problem-solving.

• Record of scientific oral communication with internal and/or external visibility.

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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