Drug Development Training Program, Translational Medicine

The Drug Development Training Program (DDTP) within Genentech's Research and Early Development (gRED) function gives recent doctoral graduates the opportunity to gain specific on the job training in one of gREDs main functional R&D units. In 2025, we are hiring 3 positions in Translational Medicine (Omni-Biomarker), Development Sciences (Translational Safety) and gRED Computational Sciences (Computational Catalyst).

The aim of the DDTP is to bring Early-in-Career doctoral graduates (PhD, MD/PhD, DVM or equivalent) to Genentech for hands-on training and mentorship in specific functions involved in multiple areas of pre-clinical and clinical drug development. The goal of the DDTP program is to prepare participants with the scientific skills and drug development experience required to perform as an independent scientist in a top-notch biomedical research organization.

DDTP trainees will spend their full 3 years in one of the functions of the Translational Medicine, Development Sciences, or Computational Science organizations, located in South San Francisco, California. This position is onsite with no remote options. At the end of the three-year period, successful participants should have the experience/skills needed to be successful in a Scientist position at Genentech or at another top-notch drug development organization. Throughout the program, participants are considered full-time employees of their assigned department and are eligible for Genentech's employee benefits.

This position is located at Genentech, in South San Francisco and is an onsite role.

Program Start Date: August 2025- December 2025 (flexible within this time frame)

Length of Assignment: 3 years

Education Level: Recent graduates of a doctoral program (PhD, MD/PhD, DVM) or in the final year of doctorate in a relevant field. Recent graduates are defined as being within two years since graduating from a doctoral program.

Translational Medicine (TM) develops and executes innovative biomarker strategies to drive clinical development through all phases of the portfolio, and conduct foundational disease-oriented translational research to maximize our scientific and clinical impact. We are seeking a highly motivated and talented fellow to join Genentech's innovative translational research & discovery efforts in the TM-OMNI (Ophthalmology, Metabolism, Neuro and Immunology) group.

The successful candidate will complete a lab-based project and acquire critical knowledge of the core techniques and biological assays required to establish disease-oriented, translational research models of Inflammatory Bowel Disease (IBD) with potential to characterize our portfolio molecules, deliver pathway biomarkers and discover new biology that can impact our current and future pipeline.

The Opportunity:

• Develop and compare complex in vitro/ex vivo models of human Inflammatory Bowel Disease (IBD).

• Design studies to characterize new in vitro IBD models for disease pathobiology and cell phenotypes that recapitulates the disease using assays, including, but not limited to, imaging, immunoassays and multi-omics platforms.

• Evaluate the molecular pathway perturbations of pipeline anti-fibrotic molecules introduced to the model system to inform the clinical biomarker strategies for these molecules.

• Contribute to the advancement of state-of-the-art bioengineering approaches and techniques.

• Process and analyze data, interpreting results in alignment with the overarching scientific objectives.

• Actively participate in team and departmental meetings, fostering effective collaboration with peers and fellow researchers.

Who You Are:

PhD, MD/PhD, DVM or equivalent in Immunology, Cell / Molecular Biology, Biochemistry, Biological engineering or related disciplines with a strong academic performance and publication record.

Required Skills:

• Detail-oriented and self-directed individuals with hands-on experience in molecular biology (RT-qPCR, immunoassays including ELISA) and cell biology (mammalian cell culture) techniques.

• Experience with primary cell isolation from tissue or co-culture models containing multiple cell types and/or fibroblasts is a plus.

• Expertise working with primary immune cells; developing immune cell co-culture models is a plus.

• Bioinformatics experience in R or Python.

• Strong experimental design, troubleshooting, and protocol optimization skills.

• Strong interest in learning drug development and pursuing a career in industry.

Other Preferred Knowledge, Skills, and Qualifications

• Experience with imaging (immunofluorescence/confocal microscopy, timelapse, etc.).

• Experience developing complex in vitro model systems, such as organoids, microphysiological systems (MPS), or primary 3D cell culture models.

• Excellent communication, collaboration, and interpersonal skills.

• Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

How to Apply:

• CV listing publication record (no max on page limit), required

• Cover letter (2-pages max) expressing your interest in the position and your future career plans, optional but strongly encouraged

• Title Your PDF "First Name_Last Name_DDTP_Application" (e.g. Aisha_Aimes_DDTP_Application)

• Do not submit additional documents (e.g. letters of recommendation, publications, transcripts, etc.), at this time.

• Deadline to apply is Friday, February 7, 2025 12PM PST

Please apply to only one of the 3 DDTP positions that aligns with your interests and qualifications.

To learn more about DDTP, please see the link below:

https://go.gene.com/DDTP2025-InfoSessionRecording

Not sure you meet all qualifications? Let us decide! Research shows that women and members of other under-represented groups tend to not apply to jobs when they think they may not meet every qualification, when, in fact, they often do! We are committed to creating a diverse and inclusive environment and strongly encourage you to apply.

The expected salary range for this position based on the primary location of South San Francisco California is $120,700 and 224,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are available for this job posting.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.