Senior Scientist II, Preclinical Drug Safety

How will your role help us transform hope into reality?

As a key member of the Preclinical Drug Safety team, you will be responsible for developing and implementing toxicology strategies for multi-disciplinary project teams. You will play a critical role helping derisk and advance the research pipeline by leveraging your toxicology expertise, including a blend of in-vitro and in-vivo skills. You will be a key member of the larger Quantitative Translational Pharmacology (QTP) group, which in addition to Preclinical Drug Safety includes In-vivo Pharmacology, DMPK, and Clinical Pharmacology. Implementing toxicology strategies will require effective collaboration with Blueprint colleagues within QTP and with other functions in the research space. Key activities will include target safety evaluation, helping optimize lead series compounds and nominate development candidates (DC's) and, ultimately, support IND submissions. You will provide technical expertise and bring a sense of urgency to help project teams advance the Blueprint portfolio and deliver differentiated therapies to patients.

What will you do?

• Help multidisciplinary project teams navigate compound safety risks through various stages of drug discovery and preclinical development, including lead series optimization and development candidate (DC) nomination.
• Design, monitor, and interpret toxicology and safety pharmacology data from investigative, non-GLP and, ultimately, GLP-compliant toxicology studies conducted both internally and/or at Contract Research Organizations (CROs).
• In addition to independent team representation, partner with more senior members of the Preclinical Drug Safety as needed. Through these partnerships, you may help support cross-functional strategic initiatives and/or project teams in later stages of development
• As needed, collaborate with colleagues within QTP (e.g., Pathology, In-vivo Pharmacology, DMPK, or Clinical Pharmacology) and with other functions in Blueprint (e.g., Medicinal Chemistry, Biology, Translational Medicine, Pharmaceutical Sciences, among others).

What minimum qualifications do we require?

• PhD in toxicology, pharmacology, or a related discipline with a minimum of 3 years industry experience

What additional qualifications will make you a stronger candidate?

• Understanding of technical principles and basic methodologies for computational and/or in-vitro hazard identifications/ risk assessments in a pharmaceutical setting
• Experience in designing and executing in-vivo nonclinical toxicology studies to characterize the pharmacologic/ toxicologic properties of compounds, including those performed at CRO's
• Demonstrated ability to interpret toxicology data in the context of a compound's pharmacokinetic profile
• Ability to successfully influence multidisciplinary project teams and operate effectively in a matrixed environment
• Ability to thrive in a fast-paced, dynamic environment and deliver under tight timelines.
• Demonstrated proficiency with basic project management skills.
• Strong interpersonal, collaborative, and scientific communication skills.
• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators - the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion. A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We are also an E-Verify Employer. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com.

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement.

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

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