Postdoctoral Research Associate - In vivo 2-photon neural circuit imaging - Zakharenko Lab

Employer

St. Jude Children's Research Hospital

Location

Memphis, Tennessee

Salary

Commensurate with experience

Closing date

Oct 23, 2025

A postdoctoral position is available for a highly motivated individual interested in the neural circuit mechanisms of schizophrenia. Our laboratory conducts 2-photon laser-scanning microscopy imaging of neuronal activity in mutant mice, with a focus on mouse models of 22q11 and 3q29 deletion syndromes, high-risk genetic risks for developing psychiatric disorders, especially schizophrenia.

Our laboratory conducts 2-photon laser-scanning microscopy imaging of neuronal activity in awake mice, with a focus on mouse models of genetic risks for developing schizophrenia. Preference will be given to applicants who have received their Ph.D. degrees in computational neuroscience, physics, mathematics, computer science, or related fields within the last 3 years and have experience in computational neuroscience and data mining using machine learning methods.

The successful candidate will lead an independent research project dedicated to identifying abnormal neuronal activities in circuits of murine models of 22q11.2 and 3q29 deletion syndromes, two rare conditions that confer the highest genetic risks of schizophrenia.

Qualifications:

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  PhD in neuroscience, or related fields

  
  
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  Optogenetics and chemogenetics

  
  
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  Demonstrated hands-on experience with 2-photon imaging techniques

  
  
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  Experience analyzing time-series data, preferably from neuroimaging or behavioral studies

  
  
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  Excellent communication skills and ability to work in a collaborative environment

  
  

Preference will be given to applicants who have received their M.D. or Ph.D. degrees in Neuroscience within the last 3 years and have experience in 2-photon imaging in freely behaving or head-fixed animals, single-cell electrophysiology, computational neuroscience, and data mining using machine learning methods.

The laboratory is equipped with Mini-2p (Thorlabs) for imaging neuronal activity in behaving animals, two 2-photon mesoscopes (Thorlabs) for imaging large cortical and subcortical areas in awake head-fixed animals, two 2-photon microscopes for single-cell electrophysiological experiments in brain slices (Chun et al, Science 2014; Blundon et. al. Science 2017; Davenport et al., Cell 2022; Bayazitov et al., Cell Reports 2024, Patton et al., Cell Reports 2024; Eom, et al, Nature Communications 2024).

The successful candidate will join a diverse team of researchers whose efforts are directed toward understanding behavior at the levels of neural circuits, individual neurons, synapses, and molecules. The laboratory is part of the Department of Developmental Neurobiology, which houses specialized departmental shared resources, including an integrated support structure for rodent behavior testing, brain organoids, in vivo and ex vivo cellular imaging, bioinformatics, production of genetically engineered animal models, single-cell profiling, and advanced image processing and analysis. In addition, numerous institutional shared resources and core facilities support the laboratory by providing expertise and state-of-the-art technologies.

St. Jude Children's Research Hospital offers an excellent salary and benefits package and is an equal opportunity employer. Interested applicants should send their CVs and the names and addresses of 3 references to:

Stanislav Zakharenko, M.D., Ph.D.

Department of Developmental Neurobiology, MS 322

St. Jude Children's Research Hospital

262 Danny Thomas Place

Memphis, TN 38105

stanislav.zakharenko@stjude.org

St. Jude is an Equal Opportunity Employer

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