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Principal Investigator, DMPK

Incyte Corporation
United States, Delaware, Wilmington
1801 Augustine Cut Off (Show on map)
Aug 13, 2025
Overview

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Incyte Drug Metabolism & Nonclinical Pharmacokinetics (DMPK) group is seeking a highly motivated and well accomplished DMPK project representative able to provide strategic DMPK support of discovery and nonclinical development programs. The incumbent will be an integral project team member representing DMPK on small molecule and biologics research projects to ensure effective integration of ADME, PK, and PKPD into the team strategy.

Job Responsibilities:

  • Serve as a DMPK project lead on discovery project teams. Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build thorough knowledge of drug candidate properties.
  • Responsible for the design and interpretation of preclinical DMPK studies necessary for the selection of clinical candidates.
  • Ensure adequate characterization and liability assessment to support candidate nomination and clinical dose projections.
  • Responsible for writing PK reports, and author DMPK sections for regulatory submissions and IB updates.
  • Develop interdisciplinary collaborations and ensure that key DMPK data, information, and priorities are integrated into overall project team strategy.

Minimum Requirements

  • PhD or equivalent with 5+ years of industry experience in PK.
  • Strong working knowledge of ADME (in vitro, in vivo, in vitro-to-in vivo) and pharmacokinetics with hands-on experience using PK software tools (e.g., WinNonlin, Gastroplus) is required. Knowledge and expertise in modeling such as PBPK and PK/PD is preferred.
  • Experience as a DMPK project lead in discovery programs is preferred.
  • PK knowledge and experience with biologics and protein degraders is a desirable plus.
  • Appropriate understanding of applicable FDA and European regulations with experience in IND filing and clinical protocols is a plus
  • Excellent oral and written communication skills are essential along with strong organizational skills.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

We Respect Your Privacy

Learn more at: http://www.incyte.com/privacy-policy

The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.

During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process here.

You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work.

You can learn more about Incyte's data protection practices here. By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable).

Please contact privacy@incyte.com if you have any questions or concerns or would like to exercise your rights.

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