Biochemist II

POSITION SUMMARY:

This job is responsible for manufacturing products using instruments and biochemical processes. The incumbent will utilize techniques such as size exclusion chromatography purification/analysis, oligonucleotide deprotection/conjugation, gel filtration, centrifugation, spectrophotometry, reconstitution, and various assays.

DUTIES AND RESPONSIBILITIES:

* Purify protein solutions via FPLC or spin column gel filtration to prepare conjugation/coating solutions or remove free-tag

* Utilize HPLC to perform size exclusion chromatography analysis on customer samples in order to report percentages of monomer, aggregation, and free-tag

* Manufacture products by deprotecting oligonucleotide solutions utilizing various chemistries

o Conjugate oligonucleotide solutions to various proteins

* Conjugate antibodies with Biotin or SULFO-TAG NHS-Ester in order to produce detection/capture antibodies for use in catalog and custom kits

* Quantify protein concentrations utilizing techniques such as spectrophotometry or BCA Assay

* Run assays to quantify biotin/protein ratios or glycerol content in solution

* Manufacture customer contract materials with specialized procedure and handling requirements

* Assist the Supervisor in training of new manufacturing personnel

* Review production records to ensure technicial accuracy and compliance with GDP

* Maintain preventative maintanence schedules for lab equipment

* Provide input and execute tasks to improve routine manufacturing processes that provide for better quality and quantity of products

o Update Standard Operating Procedures or Batch Records as needed

* Participate in technicial transfer of new processes into the Biochemical Manufacturing team by providing feedback on draft documents and shadowing new production processes during development.

* Participation in general laboratory maintenance including maintaining laboratory cleanliness, supplies and equipment

o Prepare, maintain and report raw material or reagent inventories.

o Participate in year-end physical inventory

* Specific duties may vary depending upon departmental requirements

EXPERIENCE AND QUALIFICATIONS:

* Bachelor's degree in Biology, Chemistry, Biotechnology, Engineering or related field; or an Associate's degree with equivalent applicable work experience.

* Two years experience in a manufacturing role utilizing biochemistry techniques

KNOWLEDGE, SKILLS AND ABILITIES:

* A demonstrated aptitude for learning and adhering to standard laboratory techniques and safety precautions

* Thorough knowledge of scientific fundamentals and analytical background

* Demonstrate a mechanical aptitude including equipment troubleshooting

* Excellent oral, written communication and interpersonal skills

o Effectively communicate issues/problems and results that impact timelines, accuracy and reliability of laboratory data

* Proficiency in MS Office Suite

* Ability to follow laboratory safety instructions; ability to use protective equipment.

* Ability to multi-task and work productively in a demanding manufacturing environment with changing priorities

* Knowledge of cGMP and/or ISO certification highly preferred

* Ability to learn additional software applications/tools, as required

* Knowledge of JDE is highly preferred

* Knowledge of FPLC or HPLC highly preferred

* Knowledge of Akta systems highly preferred

PHYSICAL DEMANDS:

* This position requires the ability to communicate and exchange information, utilize equipment necessary to perform the job, and frequent lifting up to 25 lbs.

* Up to 80% of the day may be spent at a lab bench and/or in the cleanroom

WORK ENVIRONMENT:

Standard industrial laboratory environment

COMPENSATION SUMMARY:

The annual base salary for this position ranges from $59,100 to $87,900. This salary range represents a general guideline as MSD considers other factors when presenting an offer of employment, such as scope and responsibilities of the position, external market factors, and the candidate's knowledge, skills, abilities, education and experience. Employees may qualify for a discretionary or non-discretionary bonus in addition to their base salary. These annual bonuses are intended to recognize individual performance and enable employees to benefit from the Company's overall success.

BENEFITS SUMMARY:

At MSD, we offer a comprehensive benefits package to support our employees' well-being and financial security. In addition to competitive salaries, our benefits include medical, dental, and vision coverage, along with prescription benefits. We provide a 401(k) plan with company matching, flexible spending accounts, and company-paid short- and long-term disability insurance as well as group life and accidental death and dismemberment insurance. Our offerings also encompass paid vacation, paid sick leave, paid holidays, and paid parental leave, along with an employee assistance program. Additional voluntary perks include a fitness club membership contribution, pet insurance, identity theft protection, home and auto insurance discounts, and optional supplemental life insurance.

EEO/AA STATEMENT:

MSD is an Equal Opportunity/Affirmative Action Employer. We are committed to fostering a diverse and inclusive workplace where all individuals are treated with respect and dignity. We welcome applications from all qualified candidates, making employment decisions without regard to race, color, religion, creed, sex, sexual orientation, gender identity, genetic information, marital status, national origin, age, protected veteran status, pregnancy, disability status, or any other protected characteristic. For our full EEO/AA and Pay Transparency statement, please click on the following link: https://www.mesoscale.com/en/our_company/careers/equal_employment_opportunity_statement.

Meso Scale Diagnostics uses E-Verify to validate the work eligibility of candidates.