Post-Doctoral Research Fellow in Retinal Metabolism

Job Summary

A postdoctoral position is available immediately in the newly formed lab of Dr. Charandeep Singh (https://sites.tufts.edu/singhlab/) in the Department of Ophthalmology at Tufts Medical Center, Boston, MA. The focus of Singh lab is to understand metabolic basis of retinopathy of prematurity (ROP). His lab uses stable isotope-based metabolomics, in vivo mouse models, organoids, protein biochemistry, and multiple mass spectrometry techniques to understand metabolic changes caused by hyperoxic exposure of prematurity born infants that leads to ROP. Lab uses mouse model of oxygen induced retinopathy (OIR) on regular basis. We seek self-motivated candidates with following skills:

-Experience/Interest in AAV based manipulations in vivo, genetic manipulations in culture, lentiviral vector generation, knock-in, knock-outs (prior experience not necessary).

-Experience in mouse in vivo work, preferably retina (subretinal injections, retinal flat mounts etc.)

-Experience in molecular biology techniques (qPCR, western blotting, RNA/DNA extraction)

-Interest in metabolomics and mass spectrometry (prior experience not necessary)

-Interest in in vivo stable isotope labeling (prior experience not necessary)

-Cell culture and organoid cultures (prior experience not necessary)

-Excellent communication skills and team player

The lab is located near vibrant Chinatown area in Boston. Tufts Medical Center has a MBTA T-station on campus, making it easier to commute to work.

Job Overview

This postdoc will lead and contribute to cutting-edge research projects aimed at finding mechanisms underlying retinopathy of prematurity. This position is a unique opportunity to learn metabolic tools and techniques and apply them for ROP research. The ultimate aim of the postdoc training is to help the postdoc to embark onto their journey as an independent principal investigator in future.

Work Setting/Environment:

1. Typical lab setting, requiring experimentation and desk work.

2. Managing mouse colonies.

3. Work on computer to analyze data, read/write publications, and to maintain lab notebook.

Job Description

Minimum Qualifications:

1. PHD in a relevant field of study OR M.D.

2. Prior experience in healthcare research.

Preferred Qualifications:

1. Passion for science

2. Ideal applicants have PhD in Ophthalmic research, Molecular Biology, Biochemistry, Metabolomics and related fields.

3. Prior publications in your PhD or postdoc in another lab.

Duties and Responsibilities: The duties and responsibilities listed below are intended to describe the general nature of work and are not intended to be an all-inclusive list. Other duties and responsibilities may be assigned.

1. Conducts independent research projects within the healthcare field, under the guidance and mentorship of senior researchers.

2. Designs and implements research studies, including experimental protocols, data collection methods, and statistical analysis plans.

3. Analyzes and interprets research data, using appropriate statistical techniques and software.

4. Prepares research findings for publication in peer-reviewed journals and present at conferences and scientific meetings.

5. Collaborates with other researchers and professionals to develop and refine research hypotheses, study designs, and methodologies.

6. Stays updated with the latest advancements and breakthroughs in healthcare research and apply relevant knowledge to ongoing projects.

7. Assists in securing research funding by contributing to grant writing and research proposal development.

8. Collaborates with healthcare professionals and institutions to collect clinical data and samples for research purposes.

9. Contributes to the development and validation of new diagnostic tools, treatments, and interventions.

10. Participates in the preparation of research reports, progress updates, and grant applications.

11. Mentors and provide guidance to undergraduate and graduate students involved in research projects.

12. Collaborates with industry partners to translate research findings into practical applications and technologies.

13. Collaborates with regulatory bodies and ethics committees to ensure compliance with research protocols and regulations.

14. Contributes to the dissemination of research findings to healthcare professionals, policymakers, and the general public through various channels, such as seminars, workshops, and publications.

15. Maintains accurate and organized records of research data, protocols, and results, ensuring data integrity and confidentiality.

Physical Requirements:

1. Typical clinical and administrative office setting.

Skills & Abilities:

1. Demonstrated experience in research design, data collection, statistical analysis, and scientific writing.

2. Proficiency in statistical software packages (e.g., SPSS, SAS, R) and data management tools.

3. Strong analytical and critical thinking skills, with the ability to interpret complex data sets.

4. Excellent verbal and written communication skills, including experience presenting research findings to diverse audiences.

5. Ability to work independently and collaboratively within a team environment.

6. Knowledge of ethical guidelines and regulations related to healthcare research.