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Principal Medical (Science) Director - Neuroimmunology

Genentech
United States, California, South San Francisco
Oct 03, 2025
The Position

The Opportunity

At USMA, we focus on broadening opportunities for patient access by ensuring that health care stakeholders have the evidence they need on our products and the confidence in that evidence to make informed treatment decisions. As a key pillar in the broader Genentech organization, USMA has a pivotal role in bridging internal partner functions (including Research, Product Development, Commercial, and Government Affairs) and collaborating across the dynamic health ecosystem to ultimately deliver better patient outcomes while making care more accessible and affordable for all.

The Principal Medical Director / Medical Science Director is a player/coach to a team of Medical Directors (MD)/ Medical Science Directors (MSD) and will report to the Therapeutic Area Lead. By putting patients and science at the center of all actions, they drive and guide medical strategy and tactics aimed at maximizing medical progress. They will play a critical role to establish and maintain professional relationships with key medical experts in their field and will oversee all aspects of medical product support including collaboration with the relevant stakeholders to drive timely data generation and dissemination. They are expected to maintain an in-depth understanding of the medical strategy and relevant clinical and payer issues, while ensuring Genentech's partners understand key trends and shifts in the external healthcare landscape. They understand and evaluate their team and organization's opportunities and constraints and build capabilities with an enterprise mindset. They serve as the guardian for high standards of compliance, ethics and safety.

Key Responsibilities

Who you are

  • Co-own with the team, the medical value proposition of product / pipeline & its contextualization in given therapeutic area(s) in order to implement medical strategies and tactics

  • Consistently engage with customers (patients, payers, healthcare professionals, professional societies, & cooperative groups) to understand their evolving medical needs and identify knowledge gaps & opportunities for collaboration, & scientific exchange through various channels to drive medical progress

  • Drive timely formation and execution of high quality Phase IIIb/IV clinical trials and investigator-initiated research including study design, protocol writing, approval, implementation and conduct, clinical monitoring, data interpretation and study reports

  • Maintain an in-depth understanding of relevant medical strategy in the context of the healthcare landscape & customers for the US & represent the US perspective in global conversations

  • Collaborate with key stakeholders to prioritize the most important work, meet enterprise resource needs, and ensure fluidity and flexibility of people across activities (initiatives, projects, WPTs, etc.)

  • Create a culture grounded in trust, mutual respect and transparency in decision making that empowers individuals to self-organize and prioritize, to ensure engagement and retention

  • Serve as a source for advice seeking by individual contributors on decision making; empower individual contributors closest to the work to make decisions while providing input as requested

  • Identify and address training and development needs, inspire high performance by providing strategic leadership, setting goals, removing roadblocks, providing feedback, and coaching to capabilities, and actively promote an inclusive environment by supporting coaching, mentoring, and development opportunities.

Required Qualifications & Experience

  • Advanced degree (MD, PhD, PharmD)

  • Post-graduate degree required (e.g. MD, PhD, PharmD)

  • 5+ years of pharmaceutical / biotechnology industry experience

  • Experience in drug development (Phase I-IV), medical writing, and data analysis, with a thorough understanding of US regulatory/FDA requirements.

  • Demonstrated ability to coach, mentor, and develop leaders, and to build relationships with and identify the needs of patients, providers, and payers.

  • Substantive understanding of corporate legal and compliance, including GCP, OIG, and other guiding elements of the business.

  • Proven track record of collaborating, coaching, and influencing outcomes in complex organizations and projects, embracing an agile mindset and new digital healthcare landscapes to serve patient needs.

Preferred Qualifications & Experience

  • 5+ years of Medical Affairs or Product Development or is a recognized expert in the field

  • Strong academic/teaching background

  • Previous people management experience

Travel Requirements

The position is located in South San Francisco. The position may require up to 25% time traveling.

The expected salary range for this position based on the primary location of South San Francisco, CA is $241,900 - 571,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are not available for this job posting.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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