Postdoctoral Research Associate - Gioeli Lab, Urology

The Gioeli Lab in the Department of Urology at the University of Virginia School of Medicine is seeking applicants for a Postdoctoral Research Associate to join our collaborative and highly productive research team.

The Gioeli Labis a translational cancer biology lab focused on the molecular mechanisms driving prostate cancer progression and therapeutic resistance. Our research spans three interconnected programs:

• HULLK lncRNA - mechanistic investigation of a novel lncRNA oncogene we discovered that confers anoikis resistance through dual regulation of RhoA signaling, with relevance to metastatic dissemination
• ERG oncogene inhibition - developing and characterizing small molecule inhibitors of the ERG/ETS transcription factor as a therapeutic strategy, with emerging work at the intersection of ERG, immune evasion, and checkpoint blockade sensitivity
• Androgen receptor (AR) signaling - dissecting how post-translational modifications and co-regulatory networks reprogram AR activity in castration-resistant prostate cancer

We maintain active collaborations with clinician-scientists, and bioengineers, structural biologists, and our lab is embedded within UVA's NCI-designated Comprehensive Cancer Center.

This is a full-time, 12-month appointment renewable for up to four additional one-year terms, contingent on satisfactory performance and funding availability. The position offers mentored research training under Dr. Daniel Gioeli with full support for publication of original research and career development toward an independent academic or research position.

Per UVA policy, postdoctoral appointments are generally limited to individuals who received their doctoral degree within the past five years.

Responsibilities

• Lead independent research projects in one or more of the lab's active programs
• Design, execute, and troubleshoot experiments spanning molecular biology, cell biology, and in vivo/ex vivo model systems
• Contribute to grant preparation, manuscript writing, and scientific presentations
• Collaborate with internal lab members and external partners across disciplines
• Participate in lab meetings, journal clubs, and Cancer Center activities.

Minimum Qualifications

Education: Doctoral degree in related field.

Physical Demands: This is primarily a sedentary job involving extensive use of desktop computers. The job does occasionally require traveling some distance to attend meetings, and programs.

Preferred Qualifications

• PhD (or equivalent) in cancer biology, cell biology, molecular biology, biochemistry, or a closely related field, in hand by start date
• Demonstrated hands-on research experience and a track record of productivity (publications or manuscripts in preparation)
• Background in transcription factor biology, lncRNA biology, signal transduction, or tumor immunology
• Experience with in vitro, in vivo, and ex vivo tumor model systems
• Familiarity with prostate cancer or endocrine-driven malignancies
• Strong experimental design, troubleshooting, and scientific writing skills
• Self-motivated, collaborative, and comfortable working at the interface of basic and translational science.

This is an Exempt-level, benefitted position. For more information on the benefits available to postdoctoral associates at UVA, visitpostdoc.virginia.eduandhr.virginia.edu/benefits.

This position is based in Charlottesville, VA, and must be performed fully on-site. To learn more about UVA and in the Charlottesville area, visit UVA Life and Embark CVA.

Application review will begin April 27 and will remain open until filled.Salary will be commensurate with education, experience, and NIH guidelines. Background checks and pre-employment health screenings will be conducted on all new hires prior to employment.

How to Apply

Please apply online, by searching for requisition number R0081840. Complete an application with the following documents:

• Resume
• Cover Letter

Upload all materials into the resume submission field. You can submit multiple documents into this one field or combine them into one PDF. Applications without all required documents will not receive full consideration.

Internal applicants may search and apply for jobs on theUVA Internal Careers website.

Reference checks will be completed by UVA's third-party partner, SkillSurvey, during the final phase of the interview. Five references will be requested, with at least three responses required.

For questions about the application process, please contact

Lyndsay Thaxton at enn9zv@virginia.edu.

For questions about the position, please contact Andrew Christie at ASC9D@uvahealth.org.

The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA's commitment to non-discrimination and equal opportunity employment.