Software Engineer II

The Research Informatics group is looking for a Software Engineer II to develop, maintain, and support web applications and tools utilized by Research, Early Development, and other groups within Alnylam. These tools directly support the discovery and development of RNAi therapeutics, enabling scientists to analyze data, make decisions, and accelerate progress toward new medicines. Because RNAi is a relatively new therapeutic modality, much of our work involves building custom software, ranging from data pipelines and APIs to user-facing applications and visualizations.

We are also expanding our internal AI platform, including tools for natural language querying, structured data access (e.g., text-to-SQL), and working with unstructured data. Engineers on the team contribute to these systems and help integrate them into scientific workflows. This role is a good fit for someone early in their career who has some professional experience and is excited to take on increasing ownership, contribute to real-world scientific problems, and grow within a collaborative engineering team.

This position is hybrid and will be primarily located in Cambridge, MA.

Key Responsibilities

• Work with scientists and internal users to understand needs and help design and implement software solutions
• Build, test, debug, and maintain web applications, APIs, and data-driven tools
• Ability to work independently on well-defined tasks and collaborate on more complex projects
• Contribute to the design and improvement of existing systems and workflows
• Write clear documentation (design notes, technical specs, diagrams)
• Participate in code reviews and follow established engineering best practices
• Collaborate with the team through agile ceremonies (standups, sprint planning)

Qualifications

Required

• BS in Computer Science or equivalent experience
• 1-3 years of professional software development experience
• Strong fundamentals in programming, debugging, unit testing, and problem solving
• Familiarity with version control (Git)
• Understanding of web application architecture (client/server interactions, APIs)
• Experience with one or more of the following:
  • Python
  • JavaScript / TypeScript
  • SQL

Preferred

• Experience with any of these frameworks/tools is a plus
  • Flask or similar backend frameworks
  • React or modern frontend frameworks
  • AWS or other cloud platforms
  • SQLAlchemy or ORM tooling
  • Docker or containerization
• Exposure to AI-powered tools or data workflows
• Familiarity with agile methodologies

Other

• Strong communication skills and ability to work with both technical and non-technical stakeholders
• Eagerness to learn and grow in a collaborative environment

Engineers on this team regularly see their work used directly by scientists and researchers.

#LI-JR1

U.S. Pay Range

$99,500.00 - $134,600.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.