Research Associate II - High Throughput Screening Core

Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Research Assistant II position is available within the High Throughput Screening (HTS) Core. The HTS Core supports early-stage drug discovery through assay development and optimization, high-throughput small-molecule screening, hit identification and validation, and lead optimization. The Core provides investigators with access to automated screening capabilities, a collection of more than 250,000 small molecules, and scientific expertise in biochemical and cell-based assay development.

We are seeking a highly motivated and collaborative research professional with experience in cell biology, biochemistry, assay development, and/or drug discovery. You will work closely with investigators and support the development, optimization, execution of small molecule screening, hit validation, and quantitative data analysis. The position will involve extensive hands-on laboratory work and close collaboration with HTS Core staff and investigators across multiple drug-discovery and translational research projects.

In addition to traditional HTS approaches, the HTS Core also involves advanced translational screening technologies, including 3D/organoid models imaging and profiling, high-content imaging and image-based phenotypic screening. Experience in one or more of these emerging areas would be highly valued.

As a successful candidate you will:

* Develop, optimize, validate, and miniaturize biochemical and cell-based assays for drug discovery and small-molecule screening.

* Design and execute high-throughput and medium-throughput screening campaigns, including primary screening, hit confirmation, concentration-response studies, counter-screens, and orthogonal/secondary validation assays.

* Utilize and support laboratory automation, liquid handling, multimode detection, and other screening technologies to establish efficient and reproducible drug-discovery workflows.

* Develop and apply high-content imaging and image-based phenotypic assays, including live-cell and multiparametric imaging.

* Manage multiple collaborative projects while maintaining high standards for experimental rigor, reproducibility, data integrity, documentation, and timely project execution.

* Develop and standardize protocols, provide technical guidance and training, and contribute to a collaborative multidisciplinary research environment.

Your qualifications should include:

* Bachelor's degree. Masters degree preferred

* 2+ years of related experience with a Bachelor's degree or 1+ year related experience with a Master's degree.

* Hands-on experience with biochemical and cell-based assay development, optimization, validation, and troubleshooting, including protein biochemical and reporter assays.

* Experience with mammalian cell culture and complex in vitro models, including primary cells, organoids, spheroids, 3D cultures, patient-derived models, and co-culture systems.

* Experience with high-throughput screening (HTS), compound screening, hit validation, lead-optimization workflows, and automated liquid-handling systems.

* Experience with high-content and live-cell imaging, phenotypic screening, and quantitative image analysis.

* Demonstrated ability to independently execute experiments, analyze data, troubleshoot, and maintain accurate, reproducible records, with proficiency in GraphPad, LIMS, and Microsoft Office.

* Strong organizational, communication, and collaboration skills, with the ability to manage multiple priorities, meet deadlines, work effectively across scientific teams, and write and follow protocols.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, pleaseCLICK HERE.

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